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Clinical trials for Biological Process

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    37 result(s) found for: Biological Process. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2016-004764-18 Sponsor Protocol Number: 01-17 Start Date*: 2017-07-24
    Sponsor Name:St Patrick’s Mental Health Services
    Full Title: Ketamine as an adjunctive therapy for Major Depression - a randomised controlled pilot trial: The KARMA-Dep Trial
    Medical condition: Depression
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: View results
    EudraCT Number: 2005-004373-23 Sponsor Protocol Number: ROV-BEM-2003-02 Start Date*: 2007-08-14
    Sponsor Name:LABORATORIOS FARMACEUTICOS ROVI, S.A.
    Full Title: MULTICENTRIC, RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED CLINICAL TRIAL TO EVALUATE THE EFFICACY AND THE SAFETY OF THE PROPHYLAXIS WITH BEMIPARIN 3,500 IU/day FOR 28 DAYS COMPARED TO 8 DAYS, IN V...
    Medical condition: VENOUS THROMBOEMBOLIC DISEASE IN PATIENTS UNDERGOING ONCOLOGICAL ABDOMINAL OR PELVIC SURGERY
    Disease: Version SOC Term Classification Code Term Level
    6.1 10043640 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PT (Completed)
    Trial results: View results
    EudraCT Number: 2022-002412-23 Sponsor Protocol Number: DUO2022_01 Start Date*: 2022-12-30
    Sponsor Name:MB PHARMA s. r. o.
    Full Title: A prospective, randomized, double-blind, placebo-controlled Phase I/IIA Clinical Trial to demonstrate the safety and efficacy of DUOFAG® in bacterial infection treatment in patients with surgical w...
    Medical condition: Bacterial infection with Staphylococcus aureus and/or Pseudomonas aeruginosa in the surgical wound.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-000041-40 Sponsor Protocol Number: P131 Start Date*: 2022-02-22
    Sponsor Name:Maastricht University
    Full Title: A study to investigate the effects of repeated low doses of psilocybin and ketamine on cognitive and emotional dysfunctions in Parkinson’s disease and to understand its mechanism of action
    Medical condition: Parkinson's disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-002020-37 Sponsor Protocol Number: 20/15 Start Date*: 2015-09-03
    Sponsor Name:St Patrick's Mental Health Services
    Full Title: Ketamine for relapse prevention in recurrent depressive disorder: a randomised, controlled pilot trial
    Medical condition: Recurrent depressive disorder
    Disease: Version SOC Term Classification Code Term Level
    19.0 10037175 - Psychiatric disorders 10057840 Major depression PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-006180-36 Sponsor Protocol Number: 22071-24071 Start Date*: 2011-01-18
    Sponsor Name:EORTC - European Organisation for Research and Treatment of Cancer
    Full Title: Randomized Phase III trial on postoperative chemoradiation in combination with anti EGFR-antibody versus postoperative chemoradiation in head and neck squamous cell carcinomas (HNSCC) with high ris...
    Medical condition: head and neck squamous cell carcinomas (HNSCC) with high risk of locoregional recurrence
    Disease: Version SOC Term Classification Code Term Level
    12.1 10067821 Head and neck cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Prematurely Ended) SI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-004037-17 Sponsor Protocol Number: 19_RIPH1_07 Start Date*: 2021-07-28
    Sponsor Name:Centre Hospitalier Universitaire de Martinique
    Full Title: Multicenter, randomized, open-label non-inferiority trial, comparing two antibiotic therapy periods (3 versus 7 days) in patients with mild leptospirosis and seen at the hospital in 5 French overse...
    Medical condition: Mild Leptospirosis : defined as Leptospirosis without the following severity criteria : a. Hemodynamic failure* with onset of septic shock b. Hematologic failure* with hemoglobin requiring red blo...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10024238 Leptospirosis PT
    20.0 10021881 - Infections and infestations 10024241 Leptospirosis, unspecified LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-001372-66 Sponsor Protocol Number: TACmono-100 Start Date*: 2014-07-16
    Sponsor Name:Erasmus Medical Center
    Full Title: Tacrolimus monotherapy in immunologically low-risk kidney transplant recipients: a pilot randomized-controlled study.
    Medical condition: kidney transplantation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-004169-18 Sponsor Protocol Number: Sat-CIEN-02 Start Date*: 2017-02-22
    Sponsor Name:Centro de Investigación Biomédica en Red, Enfermedades Neurodegenerativas (CIBERNED)
    Full Title: A multicenter, randomized, double-blind, placebo-controlled, 4-arm, 26 week parallel-group study to evaluate the safety, tolerability and anti-inflammatory effect of three oromucosal doses of Sativ...
    Medical condition: Patients with mild cognitive impairment of Alzheimer type or early Alzheimer dementia.
    Disease: Version SOC Term Classification Code Term Level
    19.0 10029205 - Nervous system disorders 10074616 Prodromal Alzheimer's disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-000431-32 Sponsor Protocol Number: ORTHOUNION Start Date*: 2017-05-25
    Sponsor Name:Universidad Autónoma de Madrid (U.A.M.)
    Full Title: A MULTI-CENTRE, OPEN-LABEL, RANDOMIZED, COMPARATIVE CLINICAL TRIAL OF TWO DIFFERENT DOSES OF BONE MARROW AUTOLOGOUS HUMAN MESENCHYMAL STEM CELLS PLUS BIOMATERIAL VERSUS ILIAC CREST AUTOLOGOUS GRAFT...
    Medical condition: Diaphyseal and/or metaphysodiaphyseal fractures (femur, tibia, humerus) with status of non-union
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10017085 Fracture malunion PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing) DE (Completed) FR (Ongoing) IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-000634-34 Sponsor Protocol Number: 13704501 Start Date*: 2014-05-19
    Sponsor Name:CHU Toulouse
    Full Title: IFM 2014-02 study: A randomized phase III study of Bortezomib-Melphalan 200 conditioning regimen versus Melphalan 200 for frontline transplant eligible patients with multiple myeloma
    Medical condition: Multiple Myeloma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Prematurely Ended) BE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-001327-23 Sponsor Protocol Number: ITP0815 Start Date*: 2015-06-26
    Sponsor Name:Fondazione G.I.M.EM.A. Gruppo Italiano Malattie Ematologiche dell'Adulto
    Full Title: Eltrombopag as Second line Therapy in adult patients with primary Immune Thrombocytopenia (ESTIT study) in an attempt to achieve long-term remission: a single arm multicenter phase II clinical and ...
    Medical condition: Primary Immune Thrombocytopenia
    Disease: Version SOC Term Classification Code Term Level
    18.0 10005329 - Blood and lymphatic system disorders 10043554 Thrombocytopenia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-003388-39 Sponsor Protocol Number: KDO_DC1311 Start Date*: 2015-03-26
    Sponsor Name:Masarykova univerzita
    Full Title: COMBINED ANTITUMOR THERAPY WITH EX VIVO MANIPULATED DENDRITIC CELLS PRODUCING INTERLEUKIN-12 IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS WITH PROGRESSIVE, RECURRENT OR PRIMARILY METASTATIC HIGH-RISK ...
    Medical condition: Progressive, recurrent or primarily metastatic high-risk malignities
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: CZ (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-006445-41 Sponsor Protocol Number: CTSSTS1010207V2 Start Date*: 2012-01-28
    Sponsor Name:HEALTH RICERCAE SVILUPPO SRL
    Full Title: The irreversibility of hemorrhagic shock treatment with anti-opiod neuropeptide
    Medical condition: Mortality of hemorrhagic shock grade 2 and 3 is from 50 to '80% in the first 24 hours, and morbidity and mortality betrayed is to 7 to 8 days of' 90% for Acute Respiratory Distress Syndrome and / o...
    Disease: Version SOC Term Classification Code Term Level
    14.1 10047065 - Vascular disorders 10049771 Shock haemorrhagic PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-001760-30 Sponsor Protocol Number: AR/BIOM Start Date*: 2012-11-05
    Sponsor Name:OSSERVATORIO EPIDEMIOLOGICO GISEA
    Full Title: Evaluation effects of treatment with IL-6R inhibitor on clinical response and biomarkers in patients with rheumatoid arthritis (RA) not responding to DMARDs and/or a first biological agent.
    Medical condition: Rheumatoid Arthritis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10039073 Rheumatoid arthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-002071-29 Sponsor Protocol Number: ITT012“ELISA” Start Date*: 2014-12-22
    Sponsor Name:DIPARTIMENTO DI ONCOLOGIA MEDICA USL8
    Full Title: A RANDOMIZED PROSPECTIVE MULTICENTRE PHASE II STUDY OF ANDROGEN DEPRIVATION THERAPY (ADT) PLUS RADIOTHERAPY WITH OR WITHOUT ABIRATERONE ACETATE AND PREDNISONE IN LOCALLY ADVANCED VERY HIGH-RISK PRO...
    Medical condition: LOCALLY ADVANCED VERY HIGH-RISK PROSTATE CANCER
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004864 10029002 Neoplasm of the prostate LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2005-002241-39 Sponsor Protocol Number: BO 18192 Start Date*: 2005-11-09
    Sponsor Name:F. Hoffmann-La Roche Ltd
    Full Title: A multicentre, double-blind randomised, phase III study to evaluate the efficacy of Tarceva or placebo following 4 cycles of platinum-based chemotherapy in patients with histologically documented a...
    Medical condition: Advanced (stage IIIB or IV) NSCLC previously treated with 4 cycles of a platinum-based chemotherapy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) ES (Completed) SI (Completed) GB (Completed) AT (Completed) LT (Completed) SK (Completed) PT (Prematurely Ended) DE (Completed) DK (Completed) CZ (Completed) IT (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2019-002123-15 Sponsor Protocol Number: GEICAM/2019-01 Start Date*: 2020-06-15
    Sponsor Name:GEICAM (Fundación Grupo Español de Investigación en Cáncer de Mama)
    Full Title: Phase II, randomized, open-label, international, multicenter study to compare efficacy of standard chemotherapy vs. letrozole plus abemaciclib as neoadjuvant therapy in HR-positive/HER2-negative hi...
    Medical condition: High/intermediate risk hormone receptor (HR) positive/human epidermal growth factor receptor 2 (HER2) negative breast cancer patients with indication of neoadjuvant therapy
    Disease: Version SOC Term Classification Code Term Level
    23.0 100000004864 10070575 Estrogen receptor positive breast cancer LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-007996-26 Sponsor Protocol Number: RC 47/07 Start Date*: 2008-12-15
    Sponsor Name:ISTITUTO PER L`INFANZIA BURLO GAROFOLO
    Full Title: Comparison between wound infiltration with different ropivacaine concentrations following inguinal herniotomy for postoperative analgesia in children: a randomized, double-blind, placebo-controlle...
    Medical condition: Children ASA 1-2, aged 1 to 8 years.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021945 Infiltration anaesthesia LLT
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-002443-26 Sponsor Protocol Number: OVG2012/04 Start Date*: 2012-08-17
    Sponsor Name:University of Oxford
    Full Title: A phase II, multi-centre, open labelled randomised control trial to describe immune & transcriptomic responses to trivalent inactivated vaccine (TIV) & MF59 adjuvanted influenza vaccine (ATIV) in 1...
    Medical condition: Healthy children will be immunised with two vaccines against influenza: Agrippal or Imuvac, or Fluad to study the immune responses to immunisation at a genetic level.
    Disease:
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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